Rebetol is not effective when used alone to treat hepatitis C. It should be taken with interferon alfa product like Peg-Intron or Intron A to treat chronic hepatitis C. The drug Rebetol should never be taken if one is allergic to its chemical composition, or if one has severe liver disease, hemoglobin disorders such as thalassemia, anemia, etc, autoimmune hepatitis, hemoglobin disorders such as thalassemia, anemia, etc. Rebetol should also not be consumed by females during their pregnancy and by men whose female sexual partner might be pregnant.

Rebetol can cause defects at the time of birth or even death in an unborn baby. Pregnant women should never consume this drug. Men should not consume Rebetol if his female sexual partner is pregnant. This is because the unborn baby that the female is carrying might also be harmed if a man fathers the child while he is consuming Rebetol.

The consumption of Rebetol may decrease the number of red blood cells in the body. This situation is called anemia and it can be detrimental for people who have heart disease or blood circulation problems. To avoid such situations, get your blood tested often. Other than that, vision, liver condition and thyroid function may also need to be tested. Regular visits to the doctor are recommended while consuming Rebetol. Situations that indicate immediate visits to the doctor include pale or yellowed skin, chest pain, weakness, fever, trouble breathing, etc.